Choosing a particle sizing method
There is an abundance of methods available to measure particle size in a sample, from laser diffraction and image analysis to flow imaging, dynamic light scattering and more. Each technique has its benefits and limitations for answering questions about a sample. This white paper outlines the primary methods available today, and describes a framework for picking a technique that will answer your question.
Who it is for. Formulation scientists, analytical leads and anyone about to specify a sizing instrument.
What is inside
- What each technique physically measures, and what it infers
- Where laser diffraction, DLS, image analysis and sieving disagree — and why
- Matching the technique to the question: specification, process control or release
- Polydispersity, and the point at which a single number stops being useful
- A decision table you can take to an instrument vendor
- Questions to ask before a demonstration
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Questions about this paper
Is the paper free?
Yes. It is gated by a short form so I know who is reading, not paid for.
Who wrote it?
Matthew McGann, President and Owner of Particle Analytx. Eighteen years in analytical instrument sales and marketing — see About.
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Most of what is in these papers is faster to explain in conversation, with your own material in front of us.